First case of juvenile primary bone malignant neoplasm in ancient China: A skeleton from the Northern Wei Dynasty (386–534 CE)

Discoveries of juvenile primary bone malignant neoplasm have been rare in archaeological settings. This study presents the first case as such from ancient China. An individual (M799) aged 14–17 years Dongxin cemetery Northern Wei Dynasty (386–534 CE), Datong, Shanxi Province, was found with signs neoplasm. The skeleton macroscopically examined aid computed tomography imaging. Results demonstrated that a bony outgrowth on distal one third diaphysis left femur; both osteoblastic and osteolytic processes were present lesion (about 148 mm long), highly dense lobulated exophytic mass protruded about 50 posterior aspect diaphysis. A periosteal new reaction adjacent cortex while medullary cavity invaded by lesion. Osteosarcoma considered most likely diagnosis, differential diagnoses Ewing sarcoma chondrosarcoma. Otherwise, disease had no asymmetric effect femoral length. enriches our knowledge paleoepidemiological patterns osteosarcoma other neoplasms past.